REVISED 1 2 The TRPV 4 channel is a novel regulator of intracellular Ca 2 + 3 in human esophageal epithelial cells 4 5
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چکیده
REVISED 1 2 The TRPV4 channel is a novel regulator of intracellular Ca 3 in human esophageal epithelial cells 4 5 Takashi Ueda, Michiko Shikano, Takeshi Kamiya, Takashi Joh, and Shinya Ugawa 6 7 Department of Neurobiology and Anatomy, and Gastroenterology and Metabolism, 8 Graduate School of Medical Sciences, Nagoya City University, Nagoya, Japan 9 10 Running head: TRPV4 in human esophageal epithelial cells 11 12 Corresponding Author: 13 Takashi Ueda, Ph.D., 14 Department of Neurobiology and Anatomy, 15 Graduate School of Medical Sciences, 16 Nagoya City University, 17 1 Kawasumi, Mizuho-cho, Mizuho-ku, 18 Nagoya, Aichi 467-8601, Japan. 19 Tel: +81-52-853-8126 20 Fax: +81-52-852-8887 21 E-mail: [email protected] 22 23 Articles in PresS. Am J Physiol Gastrointest Liver Physiol (April 14, 2011). doi:10.1152/ajpgi.00511.2010
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The TRPV4 channel is a novel regulator of intracellular Ca2+ in human esophageal epithelial cells.
The esophageal epithelium has sensory properties that enable it to sustain normal barrier function. Transient receptor potential vanilloid 4 (TRPV4) is a Ca(2+)-permeable channel that is activated by extracellular hypotonicity, polyunsaturated fatty acids, phorbol esters, and elevated temperature. We found that TRPV4 is expressed in both human esophageal tissue and in HET-1A cells, a human esop...
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